DICER cleavage fidelity is governed by 5′-end binding pockets

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I wouldn’t necessarily recommend trying to cultivate a guilty displeasure as part of your identity. It’s probably better to focus on positive rather than negative things, though I allow an exception for things that are overabundant and not that good for you, for which snobbery is a totally valid defensive strategy. Similarly, some guilty pleasures are probably better kept a little guilty, if they clash with who you aspire to be. But in general, it’s better to be a confident, self-loving person, and identifying guilty displeasures, so that you can decide what to do with them, seems like a good first step.

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